Over 10,000+ customers' choice, Focus on screening industry 40+ years
The characteristics of pharmaceutical granules are closely related to the formulation, binder content, drying conditions, and granulation method. Different formulations and production processes can result in granules with varying strength, brittleness, particle size, and surface characteristics.
Several factors during screening deserve attention.
Repeated Particle Impact
As granules move across the screen surface, they may collide with the screen mesh, screen frame, or other particles. For granules with relatively low mechanical strength or high brittleness, repeated impacts may cause breakage.
Friction Between Particles
Continuous movement and contact between granules may create friction. Depending on the material properties and operating conditions, this can result in surface abrasion and the generation of fine particles.
Screening Parameters That Do Not Match Material Properties
Different granules respond differently to vibration intensity, screening time, and feed rate. Inappropriate operating parameters may create an unsuitable movement pattern and affect the condition of the material.
Therefore, pharmaceutical granule screening should not focus solely on high vibration intensity or processing speed. The physical properties of the granules should also be considered when balancing screening performance and particle integrity.
A rotary vibratory sieve uses a vibrating motor to generate excitation force, causing materials to move along a specific trajectory across the screen surface. Particles are then separated according to their size in relation to the mesh openings.
For pharmaceutical applications, gentle classification does not simply mean reducing vibration. It involves matching equipment settings and structural configurations to the material properties and screening objectives.
1. Match Vibration Parameters to Reduce Unnecessary Impact
Vibration parameters influence how granules move across the screen surface. For materials with different strengths and particle sizes, suitable operating conditions can be evaluated through material testing. The goal is to achieve the required separation while minimizing unnecessary particle collisions.
2. Optimize Feeding to Prevent Localized Material Accumulation
If material is fed too quickly or concentrated in one area, it may accumulate locally on the screen surface, affecting particle distribution and screening conditions. Appropriate feeding arrangements and feed rates can help distribute materials more evenly across the screen.
3. Select Suitable Screen Mesh Specifications
Mesh aperture size, open area, and screen structure all influence screening performance. Screen specifications should be selected according to the target particle size range, granule shape, and required processing capacity.
4. Set an Appropriate Screening Duration
The time granules remain on the screen can influence classification results. Insufficient screening time may affect separation performance, while unnecessarily prolonged operation may increase contact and friction between particles. The appropriate screening duration should be determined according to material properties and process requirements.
Particle size distribution is an important process parameter in pharmaceutical manufacturing. It may influence subsequent operations such as blending, material transfer, and filling.
For certain solid dosage applications, particle size distribution is associated with powder flowability, blend uniformity, and downstream processing performance. Screening conditions should therefore be selected according to the required particle size range, while changes in granule characteristics before and after screening should also be monitored.
With suitable screen mesh specifications, a rotary vibratory sieve can classify pharmaceutical granules and separate oversized particles or fines that fall outside the target size range. This helps prepare materials for subsequent production operations.
It is important to note that particle size control alone does not determine final dosage form quality. Moisture content, formulation composition, granulation conditions, blending parameters, and subsequent tablet compression or capsule filling processes can also influence the final product. Screening equipment primarily performs particle size separation and should be integrated with the overall manufacturing process.
For pharmaceutical manufacturers, selecting screening equipment involves more than screening accuracy and processing capacity. Granule strength, sensitivity to breakage, and actual production conditions should also be taken into consideration.
Gaofu Machinery can provide rotary vibratory sieve configuration recommendations based on pharmaceutical granule properties and process requirements. Factors such as screen mesh specifications, screening layers, feeding arrangements, operating parameters, and auxiliary components can be evaluated during equipment selection.
When developing a screening solution, manufacturers can focus on the following aspects:
Select screen aperture sizes and screening layers according to the target particle size range.
Evaluate suitable vibration conditions based on granule strength and brittleness.
Match feeding arrangements and processing capacity to production requirements.
Consider equipment structure and disassembly methods in relation to cleaning and maintenance procedures.
Conduct material testing to evaluate particle size distribution and changes in fine-particle content before and after screening.
Gentle screening is about finding the right balance between classification performance and particle integrity.
Gaofu Machinery focuses on the screening requirements of pharmaceutical granule applications and provides rotary vibratory sieve configuration recommendations based on actual operating conditions. Suitable equipment selection can help optimize the granule classification process and support material preparation for downstream pharmaceutical manufacturing.
Pharmaceutical Industry Client Testimonials
Dong-E E-Jiao, Harbin Pharmaceutical Group, North China Pharmaceutical,Yangtze River Pharmaceutical Group, Taiji Group, Huadong Medicine,CSPC Group, Northeast Pharmaceutical, Guangzhou Baiyunshan, Tongrentang,Huiren Pharmaceutical, Fosun Pharma, Xiuzheng Pharmaceutical, Lijun Pharmaceutical,Luye Pharma Group, Di'ao Group, TianGongLi, Hengrui Medicine, Jiuzhitang, Jiangzhong Pharmaceutical, Lunan Pharmaceutical, Yunnan Baiyao, Sunflower Pharmaceutical,China Sanjiu Enterprise Group, Sanjin Pharmaceutical, Yiling Pharmaceutical,Wantong Pharmaceutical, Pientzehuang, Ma Yinglong Pharmaceutical, Guangyuyuan,Aodong Pharmaceutical, Besunyen, Jingfukang Pharmaceutical, Furen Pharmaceutical Group,Guizhou Bailing, Conba, Huasu Pharmaceutical, Yifang Pharmaceutical
Fortune 500 Client Testimonials
CNPC、CSCEC、Sinochem Holdings、CRCC、China Minmetals Corporation、CNOOC、CR、Sinopharm、CHN Energy、COFCO Corporation、Huawei Technologies、PowerChina、CITIC Group、Wuchan Zhongda Group、NORINCO、Chalco、CNBM、 Shaanxi Coal and Chemical Industry Group、Ansteel Group、CETC、CSSC、CASC、CEC、Jinchuan Group、CASIC、Conch Cement、CNNC、SPH、Shanxi Coking Coal Group、 Zhongtai Chemical、GPHL、DEC、Sinosteel Corporation、MCC、China National Salt Industry Chemical、China Baowu Steel Group、China Animal Husbandry Industry Co., Ltd.、CECEP
About Gaofu
Xinxiang Gaofu Machinery Co., Ltd. was founded back in the 1980s. With over 40 years of development, it has been certified as a National-level Specialized, Refined, Unique & Innovative Little Giant Enterprise, National Green Factory, National High-tech Enterprise, and National Intellectual Property Advantage Enterprise, and serves as the President Unit of China Vibration Screening Industry Association.
The company is accredited with the Henan Provincial Industrial Design Center, Henan Provincial Engineering Technology Research Center for Intelligent On-line Screening System, and Xinxiang Municipal Engineering Technology Research Center for Fine Screening.
Gaofu has obtained more than 500 patents including invention patents, utility model patents and design patents, been awarded the Science and Technology Achievement Prize issued by the Ministry of Industry and Information Technology of China, and participated in drafting and formulating 4 national standards.
Gaofu's product portfolio covers multiple series and hundreds of specifications, including vibrating screening equipment, conveying equipment, coal crushing equipment, filtration equipment and automatic material handling systems.
Core products include vibrating screens, screening machines, vibratory sifters, rotary vibrating screens, ultrasonic vibrating screens, linear vibrating screens, airflow screens, gyratory screens, roller screens, dewatering screens, bar screens, vacuum feeding machines, dust-free feeding stations, bulk bag feeding stations, feeding systems, automatic powder feeding systems, automatic slag-discharging filters, leaf filters, clay filters, toothed roll crushers, coal crushers and other machinery.
These products are widely applied in food, pharmaceutical, chemical, metallurgy, construction materials, mining, thermal power, environmental protection and many other industries, winning recognition and trust from over 10,000 clients worldwide.
Gaofu products enjoy strong sales across Greater China, and are exported to more than 100 countries and regions such as Russia, Canada, the United States, New Zealand, Japan, Brazil and South Africa.
Upholding the corporate mission of Improving material quality & efficiency to fully satisfy customer demands, Gaofu maintains long-term partnerships with clients to achieve win-win development.
At present, Gaofu is an official qualified supplier for numerous Fortune Global 500 enterprises, including CNPC, Sinopec, Sinochem Holdings, China Resources Group, Sinopharm Group, COFCO, China National Building Material, China Aerospace Science and Technology Corporation, Jinchuan Group and more.
Gaofu Machinery ranks No.1 in global sales volume of vibrating screens.
In May 2024, Frost & Sullivan, a world-renowned international consulting firm, issued a Market Position Verification Certificate confirming that Gaofu achieved the world's largest shipment volume of vibrating screens in the global market in 2023.
