SCREENING

Why Use Gaofu Vibrating Sifters For Pharmaceutical Powder?

Pharmaceutical powder screening is not just "simple particle separation", but a core process that connects "safety, compliance, effectiveness, stability and economy". Its quality directly determines whether the drug can meet clinical medication needs and regulatory requirements. It is an irreplaceable key link in pharmaceutical production.

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Removing foreign impurities: Pharmaceutical raw materials may be contaminated with impurities such as metal shavings, sand, gravel, fibers, and microbial carriers during collection, grinding, and transportation. If these impurities are not removed through screening, they can enter the formulation and cause serious safety issues.

Controlling "critical particle size": Some pharmaceutical powders have strict particle size requirements. The presence of extremely coarse particles can cause irritation at the administration site. The presence of ultrafine dust (such as those that are easily hygroscopic or oxidizable) can increase the risk of moisture absorption and agglomeration due to their large specific surface area, and even lead to chemical stability issues (such as degradation and the production of toxic impurities).

Ensuring dosage uniformity: Oral solid dosage forms require a uniform mixing of the active ingredient and excipients (such as fillers and binders). Excessive particle size variations (such as stratification of coarse and fine particles) can result in "content uniformity failure"—some formulations may contain excessive amounts of active ingredients (potentially leading to toxic side effects) while others may contain insufficient amounts (resulting in ineffective therapeutic effects). Screening can ensure that the particle sizes of raw materials and excipients are matched, avoiding the "particle size stratification effect" (coarse particles sinking and fine particles floating) that affects uniformity during mixing.

Range of Solutions For Pharmaceutical Powder Sieving Machine

Coarse screening (particle size > 100 μm, such as for removing impurities from raw materials): A rotary vibrating screen with a lower mesh size (e.g., 20-80 mesh) can be used.

Fine screening (particle size < 100 μm, such as for grading powders for pharmaceutical preparations): A high-precision vibrating screen (such as an ultrasonic vibrating screen, to prevent fine powder from agglomerating and clogging the screen) is required.